Commentary on Faught and Brodie
نویسنده
چکیده
When a new antiepilepsy agent is being evaluated it is critical, but not always feasible, to have access to two different kinds of information. The first is efficacy data from rigorous, prospective, randomized double-blind trials. The second is information on the drug’s ‘‘effectiveness’’ in a large population of patients, with a broad spectrum of seizure types, who are treated in a more ‘‘real world’’ situation. With zonisamide, we are fortunate to have an abundance of both kinds of information. The data from the controlled clinical trials reported by Drs. Faught and Brodie complement those from preand postmarketing studies conducted in Japan. On the one hand, clinicians can be confident that zonisamide is safe and works well in refractory partial seizures, as demonstrated in US and European pivotal trials, and that its efficacy appears be similar to, if not better than, other new antiepilepsy drugs (AEDs), such as gabapentin, lamotrigine, tiagabine, and topiramate, which have been evaluated in the same way. Nevertheless clinicians may not be sure exactly where zonisamide fits into their clinical practice because it has been tested in the type of patients dissimilar to the patients they see every day. With access to data on the use of zonisamide over a 10-year-period in Japan, clinicians in the United States and Europe
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عنوان ژورنال:
- Seizure
دوره 13 شماره
صفحات -
تاریخ انتشار 2004